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Article

Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function.

The Journal of clinical investigation - 1 Jun 2016

Margolis Kara Gross, Li Zhishan, Stevanovic Korey, Saurman Virginia, Israelyan Narek, Anderson George M, Snyder Isaac, Veenstra-VanderWeele Jeremy, Blakely Randy D, Gershon Michael D

Abstract excerpt

Autism spectrum disorder (ASD) is an increasingly common behavioral condition that frequently presents with gastrointestinal (GI) disturbances. It is not clear, however, how gut dysfunction relates to core ASD features. Multiple, rare hyperfunctional coding variants of the serotonin (5-HT) transporter (SERT, encoded by SLC6A4) have been identified in ASD. Expression of the most common SERT variant (Ala56) in mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27111230
DOI: 10.1172/JCI84877
PMCID: PMC4887174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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