Article

The LHA–DMV GABAergic Pathway Drives Constipation-predominant Irritable Bowel Syndrome via Modulating Colonic TRPV4

2026-06-19

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Brain–gut axis dysfunction underlies constipation-predominant irritable bowel syndrome (IBS-C). The lateral hypothalamic area (LHA) and dorsal motor nucleus of the vagus (DMV) regulate autonomic and gastrointestinal functions. This study investigated the role and mechanism of the LHA–DMV GABAergic pathway in IBS-C pathogenesis. <bold>Methods:</bold> IBS-C w...

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Literature Corpus work: d054eb3a-edec-54b3-9a3b-74b8d9c04275
DOI: 10.21203/rs.3.rs-9841351/v1

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