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An unbiased drug screen for seizure suppressors in Dup15q syndrome reveals 5HT <sub>1A</sub> and dopamine pathway activation as potential therapies

2020-02-19

Abstract excerpt

Duplication 15q syndrome (Dup15q) is a rare neurogenetic disorder characterized by autistic features and difficult to control (pharmacoresistant) epileptic seizures. Most individuals with isodicentric (idic15) have been on multiple medications to control their seizures and some are still seizing after years of treatment. We recently developed a model of Dup15q in Drosophila by elevating levels of fly Dube3a in gli...

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Literature Corpus work
2245bc0f-0b8b-561b-adcd-638933dd7a10
DOI
10.1101/2020.02.18.954560
Open publication

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An unbiased drug screen for seizure suppressors in Dup15q syndrome reveals 5HT <sub>1A</sub> and dopamine pathway activation as potential therapiesDOI 10.1101/2020.02.18.954560
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