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Article

RO4938581, a GABAA-α5 negative allosteric modulator rescued behavioral and EEG phenotypes of a mouse model of Dup15q syndrome.

Molecular psychiatry - 1 Mar 2026

Nakagawa Ryoko, Nani Francesca, Hipp Joerg F, Honer Michael, Knoflach Frederic, Gasser Rodolfo, Ozmen Laurence, Tamada Kota, Fjeldskaar Fatiha, Takacs Livia, Vautheny Audrey, Morairty Stephen R, Saxe Michael, Takumi Toru, Hernandez Maria-Clemencia

Abstract excerpt

We investigated the correlation between increased gene copy number of gamma aminobutyric acid type A (GABAA) receptor α5-containing subunits and electrophysiological and behavioral phenotypes in a mouse model of Dup15q syndrome (15q dup) and tested the hypothesis that selectively inhibiting the activity of GABAA-α5 receptors may have therapeutic effects. Dup15q syndrome is a rare neurodevelopmental disorder...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 15

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Share to Receptors, GABA-A

Source

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Identifiers

PMID: 41491842
DOI: 10.1038/s41380-025-03247-y
PMCID: PMC12916284

Genes

GABRA5
GABRB3
GABRG3
UBE3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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