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Article

Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.

Nature communications - 1 Jul 2021

Tamada Kota, Fukumoto Keita, Toya Tsuyoshi, Nakai Nobuhiro, Awasthi Janak R, Tanaka Shinji, Okabe Shigeo, Spitz François, Saitow Fumihito, Suzuki Hidenori, Takumi Toru

Abstract excerpt

Maternally inherited duplication of chromosome 15q11-q13 (Dup15q) is a pathogenic copy number variation (CNV) associated with autism spectrum disorder (ASD). Recently, paternally derived duplication has also been shown to contribute to the development of ASD. The molecular mechanism underlying paternal Dup15q remains unclear. Here, we conduct genetic and overexpression-based screening and identify Necdin (Ndn) as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34210967
DOI: 10.1038/s41467-021-24359-3
PMCID: PMC8249516

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