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Article

Dup15q model mice exhibit impaired gastrointestinal motility and a constipation-like phenotype, alleviated by prucalopride.

Translational psychiatry - 2 Jun 2026

Balasuriya Gayathri K, Tamada Kota, Nomura Jun, Cirillo Carla, Takumi Toru

Abstract excerpt

Chromosome 15q duplication syndrome (Dup15q) is a neurodevelopmental disorder linked to autism spectrum disorder (ASD), involving increased copies of the 15q11.2-q13 region. About 80% of individuals with Dup15q experience gastrointestinal (GI) dysfunction, including constipation. The duplicated region encodes GABA receptor A subunits, affecting GABAergic signalling, while reduced serotonin (5-HT) levels impair...

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Identifiers

PMID: 42230559
DOI: 10.1038/s41398-026-04124-0
PMCID: PMC13444328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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