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Article

Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling.

PloS one - 15 Dec 2010

Tamada Kota, Tomonaga Shozo, Hatanaka Fumiyuki, Nakai Nobuhiro, Takao Keizo, Miyakawa Tsuyoshi, Nakatani Jin, Takumi Toru

Abstract excerpt

Autism spectrum disorders (ASDs) have garnered significant attention as an important grouping of developmental brain disorders. Recent genomic studies have revealed that inherited or de novo copy number variations (CNVs) are significantly involved in the pathophysiology of ASDs. In a previous report from our laboratory, we generated mice with CNVs as a model of ASDs, with a duplicated mouse chromosome 7C that is...

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PMID: 21179543
DOI: 10.1371/journal.pone.0015126
PMCID: PMC3002297

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