Article

Identification and characterisation of bacterial TIR domains, with particular focus on Yersinia pestis

2011-01-01

Abstract excerpt

The Toll/IL-l Receptor (TIR) domain is an essential signalling module in eukaryotic innate immune signalling pathways. Homotypic interaction between TIR domains allows the formation of a signalling platform in which molecules are able to interact and activate each other to initiate an immune signalling cascade. Proteins containing TIR domains have also been discovered in bacteria. Studies have subsequently shown t...

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Identifiers and source

Literature Corpus work: 13051c77-2640-594a-a47b-93c0235a86c0
DOI: 10.17037/pubs.00768500

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