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Article

Evolution of the TIR, tolls and TLRs: functional inferences from computational biology.

Current topics in microbiology and immunology - 1 Jan 2002

Beutler B, Rehli M

Abstract excerpt

The mammalian toll-like receptors (TLRs) are products of an evolutionary process that began prior to the separation of plants and animals. The most conserved protein motif within the TLRs is the TIR, which denotes Toll, the Interleukin-1 receptor, and plant disease Resistance genes. To trace the...

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Source

Identifiers

PMID: 12467241
DOI: 10.1007/978-3-642-59430-4_1

Genes

TLR10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12467241-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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