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Article

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors.

BMC genomics - 21 May 2007

Matsushima Norio, Tanaka Takanori, Enkhbayar Purevjav, Mikami Tomoko, Taga Masae, Yamada Keiko, Kuroki Yoshio

Abstract excerpt

BACKGROUND: Toll-like receptors (TLRs) play a central role in innate immunity. TLRs are membrane glycoproteins and contain leucine rich repeat (LRR) motif in the ectodomain. TLRs recognize and respond to molecules such as lipopolysaccharide, peptidoglycan, flagellin, and RNA from bacteria or viruses. The LRR domains in TLRs have been inferred to be responsible for molecular recognition. All LRRs include the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17517123
DOI: 10.1186/1471-2164-8-124
PMCID: PMC1899181

Genes

TLR7
TLR1
TLR4
TLR8
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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