Systematic discovery of TIR-based immune signaling systems in bacteria

Abstract excerpt

Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immunity as well as in a family of bacterial defense systems called Thoeris. Here, we systematically scanned bacterial defense islands to identify anti-phage defense systems involving TIR-mediated signaling. We detected num...

Topics

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• Archaea
• Bacteria
• Bacterial Physiological Phenomena
• Bacteriophages
• CRISPR-Cas Systems
• Genetic Variation
• Mutation
• Viral Proteins

Identifiers and source

Literature Corpus work

9b39507c-0b15-5bf5-9e37-2a9baff92bbd

DOI

10.64898/2025.12.03.692087