Article

Insights into the evolution of extracellular leucine-rich repeats in metazoans with special reference to Toll-like receptor 4

2018-02-21

Abstract excerpt

The importance of the widely spread leucine-rich repeat (LRR) motif has been studied considering TLRs, the LRR-containing protein involved in animal immune response. The protein connects intracellular signalling with a chain of molecular interaction through the presence of LRRs in the ectodomain and TIR in the endodomain. Domain analyses with human TLR1-9 reported ectodomain with tandem repeats, transmembrane doma...

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Literature Corpus work: d97834eb-cdb2-54ac-bd40-392933de6a2c
DOI: 10.1101/269241

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