Article

Canonical NLR immune receptor architecture enforces EDS1-dependency onto divergent TIR domains

2026-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Toll/interleukin-1 receptor (TIR) enzymes are prominent immune components in diverse organisms across the tree of life. In flowering plants, TIRs are often integrated into nucleotide binding leucine-rich repeat (NLR) receptors whose oligomerization-dependent biochemical activities create second messengers perceived by ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1)-family signaling complexes. TIR-NLRs a...

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Literature Corpus work: cbb4da98-5fa7-5b59-af1c-e4c63638531e
DOI: 10.64898/2026.05.20.726525

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