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Reciprocal causation mixture model for robust mendelian randomization analysis using genome-scale summary data

2021-08-17

Abstract excerpt

<title>Abstract</title> <p>Mendelian randomization (MR) using GWAS summary statistics has become a popular method to infer causal relationships across complex diseases. However, the widespread pleiotropy observed in GWAS has made the selection of valid instrumental variables (IVs) problematic, leading to possible violations of MR assumptions and thus potentially invalid inferences concerning causation. Furthermor...

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Literature Corpus work
0d4a3647-1473-5fc2-ad7b-c6c9b2cdaba6
DOI
10.21203/rs.3.rs-719945/v1
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Reciprocal causation mixture model for robust mendelian randomization analysis using genome-scale summary dataDOI 10.21203/rs.3.rs-719945/v1
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