Article
Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.
Mechanisms of ageing and development - 1 Jul 2017
Giuliani Cristina, Pirazzini Chiara, Delledonne Massimo, Xumerle Luciano, Descombes Patrick, Marquis Julien, Mengozzi Giacomo, Monti Daniela, Bellizzi Dina, Passarino Giuseppe, Luiselli Donata, Franceschi Claudio, Garagnani Paolo
Abstract excerpt
In this review, we address the genetic continuum between aging and age-related diseases, with particular attention to the ecological perspective. We describe the connections between genes that promote longevity and genes associated with age-related diseases considering tradeoff mechanisms in which the same genetic variants could have different effects according to the tissue considered and could be involved in...
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