Article

Primary cilia promote resistance to EGFR tyrosine kinase inhibitor, osimertinib, in non–small cell lung cancer

2026-03-05

Abstract excerpt

Patients with advanced non–small cell lung cancer (NSCLC) and mutations in epidermal growth factor receptor (EGFR) benefit from EGFR tyrosine kinase inhibitors (TKIs). Osimertinib, a third-generation EGFR TKI, is standard first-line therapy for EGFR-mutated NSCLC, but most patients develop resistance to it. Here, we demonstrate that increased formation of primary cilia, microtubule-based sensory organelles, is ass...

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Literature Corpus work: 12d479f3-04b8-575d-aeda-98561c3b69ca
DOI: 10.64898/2026.03.03.709408

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