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Article

The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis.

Nature communications - 4 Nov 2014

Kim Miju, Kim Minchul, Lee Mi-Sun, Kim Cheol-Hee, Lim Dae-Sik

Abstract excerpt

Primary cilia are microtubule-based organelles that protrude from polarized epithelial cells. Although many structural and trafficking molecules that regulate ciliogenesis have been discovered, signalling proteins are not well defined. Here we show that the MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis. MST1 is activated during ciliogenesis and localizes to the basal body of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25367221
DOI: 10.1038/ncomms6370

Genes

MST1
SAV1
AURKA
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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