Article

ATM- and ATR-Induced Primary Ciliogenesis Promotes Cisplatin Resistance in Pancreatic Ductal Adenocarcinoma

2021-12-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of its late diagnosis and chemoresistance. Primary cilia, the cellular antennae, are observed in most human cells to maintain development and differentiation. Primary cilia are gradually lost during the progression of pancreatic cancer and are eventually absent in PDAC. However, rece...

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Literature Corpus work: 497cac21-08d1-569a-a14a-2b1d0ca3f7d5
DOI: 10.21203/rs.3.rs-942728/v1

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