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Article

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.

Scientific reports - 6 Aug 2015

Ran Jie, Yang Yunfan, Li Dengwen, Liu Min, Zhou Jun

Abstract excerpt

Cilia play important roles in sensing extracellular signals and directing fluid flow. Ciliary dysfunction is associated with a variety of diseases known as ciliopathies. Histone deacetylase 6 (HDAC6) has recently emerged as a major driver of ciliary disassembly, but little is known about the downstream players. Here we provide the first evidence that HDAC6-mediated deacetylation of α-tubulin and cortactin is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26246421
DOI: 10.1038/srep12917
PMCID: PMC4526867

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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