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Article

VHL inactivation induces HEF1 and Aurora kinase A.

Journal of the American Society of Nephrology : JASN - 1 Dec 2010

Xu Jianyong, Li Huapeng, Wang Bo, Xu Yan, Yang Jiayin, Zhang Xiaofei, Harten Sarah K, Shukla Deepa, Maxwell Patrick H, Pei Duanqing, Esteban Miguel A

Abstract excerpt

The ciliary hypothesis for cystic renal diseases postulates that most of these conditions result from abnormalities in the primary cilium, a microtubule-based structure that acts as a sensor for extracellular cues. Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes to renal cysts and clear cell renal cell carcinoma. VHL plays a critical role in the formation of primary cilia in kidney...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20864688
DOI: 10.1681/ASN.2010040345
PMCID: PMC3014016

Genes

VHL
NEDD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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VHL inactivation induces HEF1 and Aurora kinase A.PMID 20864688Read ↗

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Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD).Semantic proximity Read ↗

Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCCSemantic proximity Read ↗

Primary cilium formation requires von hippel-lindau gene function in renal-derived cells.Semantic proximity Read ↗

Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.Semantic proximity Read ↗

Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.Semantic proximity Read ↗

Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor.Semantic proximity Read ↗

Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.Semantic proximity Read ↗

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHLSemantic proximity Read ↗

Role of the<i>VHL</i>(von Hippel–Lindau) gene in renal cancer: a multifunctional tumour suppressorSemantic proximity Read ↗

AURKA promotes renal cell carcinoma progression via regulation of CCNB1 transcriptionSemantic proximity Read ↗

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