Article
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.
Nature medicine - 1 Feb 2020
Chivukula Raghu R, Montoro Daniel T, Leung Hui Min, Yang Jason, Shamseldin Hanan E, Taylor Martin S, Dougherty Gerard W, Zariwala Maimoona A, Carson Johnny, Daniels M Leigh Anne, Sears Patrick R, Black Katharine E, Hariri Lida P, Almogarri Ibrahim, Frenkel Evgeni M, Vinarsky Vladimir, Omran Heymut, Knowles Michael R, Tearney Guillermo J, Alkuraya Fowzan S, Sabatini David M
Abstract excerpt
Mucociliary clearance, the physiological process by which mammalian conducting airways expel pathogens and unwanted surface materials from the respiratory tract, depends on the coordinated function of multiple specialized cell types, including basal stem cells, mucus-secreting goblet cells, motile ciliated cells, cystic fibrosis transmembrane conductance regulator (CFTR)-rich ionocytes, and immune cells1,2....
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