Article

Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

2017-08-25

Abstract excerpt

Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer remains unclear. We have interrogated the role of cilia in acquired and de novo resistance to a variety of kinase inhibitors, and found that in several examples, resistant cells are distinctly ch...

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Literature Corpus work: df19c324-e675-5553-b6c0-5961b055bc14
DOI: 10.1101/180257

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