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Article

Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells.

Journal of cell science - 14 Dec 2018

Chowdhury Pratim, Powell Reid T, Stephan Clifford, Uray Ivan P, Talley Tia, Karki Menuka, Tripathi Durga Nand, Park Yong Sung, Mancini Michael A, Davies Peter, Dere Ruhee

Abstract excerpt

Loss of the gene von Hippel-Lindau (VHL) is associated with loss of primary cilia and is causally linked to elevated levels of Aurora kinase A (AURKA). We developed an image-based high-throughput screening (HTS) assay using a dual-labeling image analysis strategy that identifies both the cilium and the basal body. By using this strategy, we screened small-molecule compounds for the targeted rescue of cilia...

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Share to Aurora Kinase A
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to AURKA gene

Share to Gene Expression Regulation, Neoplastic

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 30518623
DOI: 10.1242/jcs.219923
PMCID: PMC6307881

Genes

VHL
AURKA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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