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Article

Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.

Current biology : CB - 11 Sept 2012

Mahjoub Moe R, Stearns Tim

Abstract excerpt

The primary cilium is a nexus of cell signaling, and ciliary dysfunction is associated with polycystic kidney disease, retinal degeneration, polydactyly, neural tube defects, and obesity (ciliopathies). Signaling molecules for cilium-associated pathways are concentrated in the cilium, and this is essential for efficient signaling. Cilia are nucleated from centrioles, and aberrant centriole numbers are seen in...

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Identifiers

PMID: 22840514
DOI: 10.1016/j.cub.2012.06.057
PMCID: PMC4094149

Genes

PKHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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