MARBL: A Live-Cell Method for Profiling Bioenergetic Heterogeneity by Noncanonical Methionine Labeling of the Cell Surface Proteome

Abstract excerpt

Heterogeneity is a hallmark of biological systems, where cell-to-cell variability supports adaptation to changing environments, but also enables maladaptive states such as drug resistance. Many sources of non-genetic variation, particularly bioenergetics and metabolism, remain difficult to measure in living cells and connect to functional outcomes. Here, we introduce MARBL (Methionine Analogues for Ratiometric Bio...

Topics

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• Energy Metabolism
• Flow Cytometry
• Inflammation
• Mitochondria
• Phenotype
• Single-Cell Analysis
• T-Lymphocyte Subsets
• T-Lymphocytes

Identifiers and source

Literature Corpus work

12c2b3f0-3946-5400-8efb-cf60ff458960

DOI

10.64898/2026.06.01.729353