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Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging

15 Jun 2023

Abstract excerpt

Stress triggers anticipatory physiological responses that promote survival, a phenomenon termed allostasis. However, the chronic activation of energy-dependent allostatic responses results in allostatic load, a dysregulated state that predicts functional decline, accelerates aging, and increases mortality in humans. The energetic cost and cellular basis for the damaging effects of allostatic load have not been...

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PMID: 37423094
DOI: 10.1016/j.psyneuen.2023.106322

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