Article

Disease-associated mutations in GluK2 disrupt compartment-specific regulatory mechanisms controlling kainate receptor membrane trafficking

2026-05-29

Abstract excerpt

Missense mutations in the Grik2 gene that encodes the kainate receptor subunit GluK2 are associated with neurodevelopmental disorders, but how individual mutations perturb receptor regulation remains unclear. To investigate how disease-associated GluK2 mutations affect receptor trafficking and signalling we used lentiviral approaches to knockdown and replace endogenous GluK2 with tagged wild-type or mutant GluK2...

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Literature Corpus work: 86d3f96b-fc6f-5c47-a859-d3a17d35b99e
DOI: 10.64898/2026.05.29.728878

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