Article

Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates

2023-02-22

Abstract excerpt

Adeno-associated viruses (AAVs) are the vector of choice for delivering gene therapies that can cure inherited and acquired diseases. Clinical research on various AAV serotypes significantly increased in recent years alongside regulatory approvals of AAV-based therapies. The current AAV purification platform hinges on the capture step, for which several affinity resins are commercially available. These adsorbents...

Identifiers and source

Literature Corpus work: 89bbf4a8-717d-533c-99ff-7e31af39ac97
DOI: 10.22541/au.167710254.46384979/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysatesDOI 10.22541/au.167710254.46384979/v1Read

Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysatesSemantic proximity Read

Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatographySemantic proximity Read

Adeno-Associated Virus Structural Biology as a Tool in Vector DevelopmentSemantic proximity Read

Reprogramming Adeno-Associated Virus Tropism Via Displayed Peptides Tiling Receptor-LigandsSemantic proximity Read

Adaptive Machine Learning Framework enables Unprecedented Yield and Purity of Adeno-Associated Viral Vectors for Gene TherapySemantic proximity Read

Production, Processing, and Characterization of Synthetic AAV Gene Therapy VectorsSemantic proximity Read

An alternate receptor for adeno-associated virusesSemantic proximity Read

Engineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography.Semantic proximity Read

PURIFICATION METHOD FOR ADENO-ASSOCIATED VIRAL VECTOR SEROTYPE 9 USING CERAMIC HYDROXYAPATITE CHROMATOGRAPHY AND ITS QUALIFICATIONSemantic proximity Read

A simplified purification protocol for recombinant adeno-associated virus vectorsSemantic proximity Read

The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapySemantic proximity Read

Anion-Exchange Chromatography at the Service of Gene Therapy: Baseline Separation of Full/Empty Adeno-Associated Virus Capsids by Screening of Conditions and Step Gradient Elution ModeSemantic proximity Read