Article

Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography

2023-05-23

Abstract excerpt

Adeno-associated viruses (AAVs) have acquired a central role in modern medicine as delivery agents for gene therapies targeting rare diseases. While new AAVs with improved tissue targeting, potency, and safety are being introduced, their biomanufacturing technology is lagging. The AAV purification pipeline, in particular, hinges on protein ligands for the affinity-based capture step: while featuring excellent AAV...

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Literature Corpus work: 277bed31-939f-52b7-a65e-54d6502d0ab5
DOI: 10.22541/au.168482798.87003310/v1

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