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Receptor-guided AAV Tropism Engineering via MATCH

2026-04-01

Abstract excerpt

Precise control over viral tropism remains a major challenge in the development of gene delivery technologies. We present MATCH (Modulation of AAV Tropism through Conjugation to Homing proteins), a modular biochemical method that enables programmable, receptor-guided retargeting of adeno-associated viruses (AAVs) through site-specific covalent protein conjugation. By incorporating a SpyTag peptide motif into selec...

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Literature Corpus work
2d7a9ee4-79e7-5bda-a429-6c6f8a303939
DOI
10.64898/2026.03.31.715691
Open publication

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Receptor-guided AAV Tropism Engineering via MATCHDOI 10.64898/2026.03.31.715691
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