Article

Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activity

2020-07-08

Abstract excerpt

TFE3 is an oncogenic transcription factor whose subcellular localization and activity are regulated by post-translational modifications. TFE3 is hyper-phosphorylated in the cytoplasm of mammalian cells under normal growth conditions, but becomes hypo-phosphorylated and translocates into the nucleus of cells with genetic inactivation of the FLCN tumor suppressor gene, which is responsible for the development of re...

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Literature Corpus work: 12a36058-e00b-56e4-bd4d-b7e04ceb9028
DOI: 10.1101/2020.07.08.193169

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