Article

SQSTM1/p62 accumulation is a hallmark of FLCN loss in Birt-Hogg-Dubé syndrome-associated kidney cancer

2026-01-14

Abstract excerpt

Birt-Hogg-Dubé syndrome (BHD) is an autosomal, dominant condition caused by Folliculin (FLCN) mutation and characterized by enhanced risk for kidney tumors. Previous studies have shown constitutive nuclear localization of the transcription factor TFEB and simultaneous hyperactivation of canonical MTORC1 signaling in the absence of FLCN. Here we assess the impact on autophagy under this situation of combined anabo...

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Literature Corpus work: af20104c-1156-594a-ad8c-fb400f563f21
DOI: 10.64898/2026.01.14.699334

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