Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Spectrum of Renal “TFEopathies”: Flipping the mTOR Switch in Renal Tumorigenesis

16 Jul 2024

Abstract excerpt

The mammalian target of Rapamycin complex 1 (mTORC1) is a serine/threonine kinase that couples nutrient and growth factor signaling to the cellular control of metabolism and plays a fundamental role in aberrant proliferation in cancer. mTORC1 has previously been considered an "on/off" switch, capable of phosphorylating the entire pool of its substrates when activated. However, recent studies have indicated that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PI3K/AKT/mTOR signaling in cancer
Share to Tuberous Sclerosis Complex Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39012319
DOI: 10.1152/physiol.00026.2024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Spectrum of Renal “TFEopathies”: Flipping the mTOR Switch in Renal TumorigenesisPMID 39012319Read ↗

TFEB and TFE3 drive kidney cystogenesis and tumorigenesisSemantic proximity Read ↗

Review: Mammalian Target of Rapamycin (mTOR) Pathway Is Critical in Developing Most Renal Cell Tumors.Semantic proximity Read ↗

TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis ComplexSemantic proximity Read ↗

The role of the Birt–Hogg–Dubé protein in mTOR activation and renal tumorigenesisSemantic proximity Read ↗

Birt-Hogg-Dubé syndrome: Clinical and molecular aspects of recently identified kidney cancer syndrome.Semantic proximity Read ↗

The molecular code of kidney cancer: A path of discovery for gene mutation and precision therapy.Semantic proximity Read ↗

Ragopathies and the rising influence of RagGTPases on human diseases.Semantic proximity Read ↗

Requirement of FLCN tumor suppressor gene for mTORC1-mediated inhibition of TFE3 transcriptional activitySemantic proximity Read ↗

mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR nodeSemantic proximity Read ↗

The genetic basis of kidney cancer: a metabolic disease.Semantic proximity Read ↗

SQSTM1/p62 accumulation is a hallmark of FLCN loss in Birt-Hogg-Dubé syndrome-associated kidney cancerSemantic proximity Read ↗

Renal cystic disease in tuberous sclerosis complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.