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Emerging roles and regulation of MiT/TFE transcriptional factors

15 Jun 2018

Abstract excerpt

The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phosphorylation. And the phosphorylated protein is retained in the cytoplasm and subsequently translocates to the nucleus upon dephosphorylation, where it stimulates the expression of hundreds of genes, leading...

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PMID: 29903018
DOI: 10.1186/s12964-018-0242-1

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