Article
FLCN-mutated oncocytic tumor in the thyroid defines a biologically distinct subset characterized by metabolic remodeling and canonical oncogenic signaling suppression.
Virchows Archiv : an international journal of pathology - 1 May 2026
Kong Weimao, Bao Longnv, Liu Zhiyan, Li Guangqi, Gu Haiyan, Allison Derek B, Zhang Wei, Lyu Shuhan, Pan Xingzhu, Liu Yanjun, Zhang Tingling, Zhang Xinyi, Wang Jigang
Abstract excerpt
Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant disorder caused by germline pathogenic variants in FLCN. Here, we describe an oncocytic tumor in the thyroid harboring pathogenic FLCN alterations. The tumor showed indolent clinical behavior and was composed of solid sheets of oncocytic cells with abundant granular eosinophilic cytoplasm. Mitochondrial genome sequencing demonstrated preserved...
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