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Article

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

Science signaling - 12 Jun 2012

Roczniak-Ferguson Agnes, Petit Constance S, Froehlich Florian, Qian Sharon, Ky Jennifer, Angarola Brittany, Walther Tobias C, Ferguson Shawn M

Abstract excerpt

Lysosomes are the major cellular site for clearance of defective organelles and digestion of internalized material. Demand on lysosomal capacity can vary greatly, and lysosomal function must be adjusted to maintain cellular homeostasis. Here, we identified an interaction between the lysosome-localized mechanistic target of rapamycin complex 1 (mTORC1) and the transcription factor TFEB (transcription factor EB),...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22692423
DOI: 10.1126/scisignal.2002790
PMCID: PMC3437338

Genes

TFEB
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.PMID 22692423Read ↗

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TFEB Signalling-Related MicroRNAs and AutophagySemantic proximity Read ↗

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processesSemantic proximity Read ↗

Emerging roles and regulation of MiT/TFE transcriptional factorsSemantic proximity Read ↗

From the regulatory mechanism of TFEB to its therapeutic implicationsSemantic proximity Read ↗

TFEB; Beyond Its Role as an Autophagy and Lysosomes RegulatorSemantic proximity Read ↗

The Role and Regulatory Mechanism of Transcription Factor EB in Health and DiseasesSemantic proximity Read ↗

Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseasesSemantic proximity Read ↗

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagySemantic proximity Read ↗

The MiTF/TFE Family of Transcription Factors: Master Regulators of Organelle Signaling, Metabolism, and Stress AdaptationSemantic proximity Read ↗

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41Semantic proximity Read ↗

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5Semantic proximity Read ↗

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