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Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways

26 Apr 2021

Abstract excerpt

is a tumor suppressor gene responsible for the inherited Birt-Hogg-Dubé (BHD) syndrome, which affects kidneys, skin and lungs. FLCN is a highly conserved protein that forms a complex with folliculin interacting proteins 1 and 2 (FNIP1/2). Although its sequence does not show homology to known functional domains, structural studies have determined a role of FLCN as a GTPase activating protein (GAP) for small...

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PMID: 33981707
DOI: 10.3389/fcell.2021.667311

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