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MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer

28 Nov 2018

Abstract excerpt

Cancer cells have an increased demand for energy sources to support accelerated rates of growth. When nutrients become limiting, cancer cells may switch to nonconventional energy sources that are mobilized through nutrient scavenging pathways involving autophagy and the lysosome. Thus, several cancers are highly reliant on constitutive activation of these pathways to degrade and recycle cellular materials. Here,...

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PMID: 31650096
DOI: 10.1146/annurev-cancerbio-030518-055835

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