Article

The CHIP–LMO7–BAG5 complex controls tau clearance and yields repurposed and newly designed therapeutic candidates for Alzheimer’s disease

2026-06-29

Abstract excerpt

Through cross-species genetic screens, we identified LMO7 as a regulator of tau levels in vivo . LMO7 bridges the E3 ligase CHIP and its inhibitory cochaperone BAG5, suppressing CHIP’s ligase activity and limiting tau ubiquitination and degradation. Adult LMO7 knockdown enhances CHIP activity, reduces total and phosphorylated tau, attenuates gliosis, and rescues memory deficits in tauopathy mice. Guided by AlphaF...

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Literature Corpus work: 129d9001-d45c-5c35-8708-d5dc55aaf7a5
DOI: 10.64898/2026.06.26.734369

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