Article

Metformin promotes broad neuroprotection and proteostatic resilience via rngo/DDI2 stabilisation

2026-02-13

Abstract excerpt

Alzheimer’s disease (AD) is one of the most common age-related causes of death, with limited effective disease-modifying treatments. Although metformin shows promise as a disease-modifying agent for AD, its molecular mechanism—specifically how it confers neuroprotection despite potentially increasing amyloid-beta (Aβ) load—remains obscure. Here, we demonstrate that metformin functions as a pharmacological activato...

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Literature Corpus work: fdaecfc0-74ae-58ab-9ee7-cf090991c861
DOI: 10.64898/2026.02.11.705245

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