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O-GlcNAcylation-Ubiquitin Crosstalk of METTL1 Drives m7G Epitranscriptomic Collapse and Lipid Metabolic Reprogramming in Diabetic Cardiomyopathy

2025-07-10

Abstract excerpt

<h4>Background</h4> Metabolic remodelling and memory in cardiomyocytes is a pivotal mechanism underlying cardiomyopathy pathogenesis. Clinical observations demonstrate persistent progression of hyperglycaemia-induced multiorgan damage following blood glucose stabilization, which is predominantly mediated through epigenetic regulation. While prior studies have identified epigenetic contributions to hyperglycaemic...

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Literature Corpus work
e2cc31ba-b072-5db5-b54d-ac90a06eee3b
DOI
10.1101/2025.07.07.663452
Open publication

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O-GlcNAcylation-Ubiquitin Crosstalk of METTL1 Drives m7G Epitranscriptomic Collapse and Lipid Metabolic Reprogramming in Diabetic CardiomyopathyDOI 10.1101/2025.07.07.663452
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