Article

A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegeneration

2022-09-19

Abstract excerpt

Neurodegenerative disorders are a family of diseases that remain poorly treated despite their growing global health burden. A shared feature of many neurodegenerative disorders is the accumulation of toxic misfolded proteins. To gain insight into the mechanisms and modulators of protein misfolding, we developed a multiplex reverse genetics platform. Using this novel platform 29 cell-based models expressing protein...

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Literature Corpus work: 616cabd7-dd59-5717-9fc5-b017bc7057bd
DOI: 10.1101/2022.09.19.508444

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