Article

Identification of Novel Mutations Causing Clofazimine Resistance in <i>Mycobacterium intracellulare</i>

2025-04-09

Abstract excerpt

Clofazimine (CFZ) is a promising repurposed drug for treating Mycobacterium avium - intracellulare complex pulmonary disease (MAC-PD), but its resistance mechanisms in M. intracellulare remain poorly understood. In this study, we generated 36 CFZ-resistant M. intracellulare mutants in vitro and identified various mutations in the marR gene (WP_009952290.1) in 61% of resistant mutants through whole-genome sequ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 125da26c-92b5-532e-8d43-5890e99214c9
DOI: 10.1101/2025.04.09.647911

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of Novel Mutations Causing Clofazimine Resistance in <i>Mycobacterium intracellulare</i>DOI 10.1101/2025.04.09.647911Read

Mutations in the <i>ubiA</i> gene are the major mechanism of ethambutol resistance in <i>Mycobacterium avium</i>Semantic proximity Read

Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysisSemantic proximity Read

The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in <i>Mycobacterium tuberculosis</i> complexSemantic proximity Read

Bedaquiline Resistance: Its Emergence, Mechanism, and PreventionSemantic proximity Read

Mutations in Rv2983 as a novel determinant of resistance to nitroimidazole drugs in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Bedaquiline- and clofazimine- selected Mycobacterium tuberculosis mutants: further insights on resistance driven largely by Rv0678Semantic proximity Read

Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine ApproachSemantic proximity Read

Clinical Characteristics, Treatment Outcomes, and Resistance Mutations Associated with Macrolide-Resistant Mycobacterium avium Complex Lung Disease.Semantic proximity Read

Drug degradation caused by <i>mce3R</i> mutations confers contezolid (MRX-I) resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Genetic determinants of intrinsic antibiotic tolerance in <i>Mycobacterium avium</i>Semantic proximity Read

In vitro approaches for generation of Mycobacterium tuberculosis mutants resistant to bedaquiline, clofazimine or linezolid and identification of associated genetic variants.Semantic proximity Read