Article

Mutations in Rv2983 as a novel determinant of resistance to nitroimidazole drugs in <i>Mycobacterium tuberculosis</i>

2018-10-31

Abstract excerpt

Delamanid represents one of two novel antimicrobial classes approved to treat tuberculosis in over 40 years. Pretomanid is another promising nitroimidazole pro-drug in clinical development. Characterization of the full spectrum of mutations conferring resistance to nitroimidazoles and their related phenotypes in Mycobacterium tuberculosis will inform development of suitable genotypic and phenotypic drug susceptib...

Identifiers and source

Literature Corpus work: 4c24e939-0405-5235-bc36-dcc40279cfcb
DOI: 10.1101/457754

Open publication

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