Article

Drug degradation caused by <i>mce3R</i> mutations confers contezolid (MRX-I) resistance in <i>Mycobacterium tuberculosis</i>

2022-07-26

Abstract excerpt

<h4>ABSTRACT</h4> Contezolid (MRX-I), a safer antibiotic of the linezolid oxazolidinone class, is a promising new antibiotic with potent activity against Mycobacterium tuberculosis (MTB) both in vitro and in vivo . To identify resistance mechanisms of contezolid in MTB, we isolated several in vitro spontaneous contezolid-resistant MTB mutants, which exhibited 16-fold increase in MICs of contezolid compared wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2da1414-63fd-5ec5-9588-2f6eea5bb400
DOI: 10.1101/2022.07.25.501497

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Drug degradation caused by <i>mce3R</i> mutations confers contezolid (MRX-I) resistance in <i>Mycobacterium tuberculosis</i>DOI 10.1101/2022.07.25.501497Read

Drug Degradation Caused by mce3R Mutations Confers Contezolid (MRX-I) Resistance in Mycobacterium tuberculosis.Semantic proximity Read

In vitro activities of contezolid (MRX-I) against drug-sensitive and drug-resistant Mycobacterium tuberculosisSemantic proximity Read

Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosisSemantic proximity Read

Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosisSemantic proximity Read

The evolution of nitroimidazole antibiotic resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Novel oxazolidinones harbor potent in vitro activity against the clinical isolates of multidrug-resistant Mycobacterium tuberculosis in ChinaSemantic proximity Read

<i>In Vitro</i> efficacy comparison of linezolid, tedizolid, sutezolid and delpazolid against rapid growing Mycobacteria isolated in Beijing, ChinaSemantic proximity Read

Identification of mutations associated with Macozinone-resistant in <i>Mycobacterium Tuberculosis</i>Semantic proximity Read

A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In VitroSemantic proximity Read

Characteristic exploration of Mycobacterium tuberculosis isolated from patients with linezolid-treated multidrug-resistant tuberculosis.Semantic proximity Read

Comparative In Vitro Drug Susceptibility Study of Five Oxazolidinones Against Mycobacterium tuberculosis in Hainan, ChinaSemantic proximity Read

A chemical-genetic map of the pathways controlling drug potency in <i>Mycobacterium tuberculosis</i>Semantic proximity Read