Novel mutations associated with clofazimine resistance in Mycobacterium intracellulare.

doi:10.1093/jac/dkaf321

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Article

Novel mutations associated with clofazimine resistance in Mycobacterium intracellulare.

The Journal of antimicrobial chemotherapy - 4 Nov 2025

Jiang Xiuzhi, Cao Dan, Qiu Yuwei, Dong Xu, Xu Pusheng, Li Yi, Yuan Xin, Xiang Yanghui, Xu Kaijin, Zhang Ying

Abstract excerpt

BACKGROUND: Clofazimine is a promising repurposed drug for treating Mycobacterium avium-intracellulare complex pulmonary disease, but its resistance mechanisms in Mycobacterium intracellulare remain poorly understood. OBJECTIVE: This study aims to elucidate the resistance mechanisms of M. intracellulare to clofazimine. METHODS: We isolated 36 clofazimine-resistant M. intracellulare mutants in vitro and performed...

Read the complete abstract on PubMed

Topics

Clofazimine
Mycobacterium avium Complex
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Mutation
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Whole Genome Sequencing

Bacterial Proteins

Genetic Complementation Test

Antitubercular Agents

Mycobacterium avium-intracellulare Infection

Anti-Bacterial Agents

Genome, Bacterial

Source

Open in PubMed

Identifiers

PMID: 40905483
DOI: 10.1093/jac/dkaf321

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