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Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach

2021-03-20

Abstract excerpt

Bedaquiline (BDQ) and clofazimine (CFZ) are core drugs for treatment of multidrug resistant tuberculosis (MDR-TB), however, our understanding of the resistance mechanisms for these drugs is sparse which is hampering rapid molecular diagnostics. To address this, we employed a unique approach using experimental evolution, protein modelling, genome sequencing, and minimum inhibitory concentration data combined with g...

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Identifiers and source

Literature Corpus work
975595ec-fc04-57eb-8c41-821719745b50
DOI
10.1101/2021.03.19.436148
Open publication

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Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine ApproachDOI 10.1101/2021.03.19.436148
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