No phenotypic resistance observed for most group-3 and -4 variants in Mycobacterium tuberculosis genes related to bedaquiline, clofazimine, delamanid, and pretomanid in a Central and West African context.

doi:10.1128/spectrum.02005-26

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

No phenotypic resistance observed for most group-3 and -4 variants in Mycobacterium tuberculosis genes related to bedaquiline, clofazimine, delamanid, and pretomanid in a Central and West African context.

Microbiology spectrum - 1 Sept 2026

Massou Faridath, Dewaele Klaas, Gnamy Anderson, Balde Ramata, Mulders Wim, Mehan Conor J, de Jong Bouke C, Affolabi Dissou, Tzfadia Oren, Rigouts Leen

Abstract excerpt

The interpretation of genetic variants' association (or not) with phenotypic resistance to newly introduced and repurposed antituberculosis drugs remains challenging, as many mutations detected by whole-genome sequencing (WGS) are classified as of uncertain significance (group 3) or not associated with resistance-interim (group 4) by the World Health Organization (WHO) mutation catalog v2. We evaluated the...

Read the complete abstract on PubMed

Topics

Mycobacterium tuberculosis
Antitubercular Agents
Microbial Sensitivity Tests
Nitroimidazoles
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Diarylquinolines

Clofazimine

Oxazoles

Whole Genome Sequencing

Africa, Western

Mutation

Africa, Central

Phenotype

Drug Resistance, Bacterial

Source

Open in PubMed Open full text

Identifiers

PMID: 42517628
DOI: 10.1128/spectrum.02005-26
PMCID: PMC13532243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No phenotypic resistance observed for most group-3 and -4 variants in Mycobacterium tuberculosis genes related to bedaquiline, clofazimine, delamanid, and pretomanid in a Central and West African context.PMID 42517628Read ↗

Characterization of genomic variants associated with resistance to bedaquiline and delamanid in naïve Mycobacterium tuberculosis clinical strainsSemantic proximity Read ↗

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.Semantic proximity Read ↗

Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical StrainsSemantic proximity Read ↗

Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid.Semantic proximity Read ↗

Investigation of genomic mutations and their association with phenotypic resistance to new and repurposed drugs in Mycobacterium tuberculosis complex clinical isolates.Semantic proximity Read ↗

Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysisSemantic proximity Read ↗

A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.Semantic proximity Read ↗

Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex.Semantic proximity Read ↗

Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine ApproachSemantic proximity Read ↗

The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samplesSemantic proximity Read ↗

Widespread loss-of-function mutations implicating preexisting resistance to new or repurposed anti-tuberculosis drugsSemantic proximity Read ↗

Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in Mycobacterium tuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.