Article

Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system

2025-11-08

Abstract excerpt

Inflammatory bowel disease (IBD) is a multifactorial disease of the gastrointestinal tract without curative treatment. Previous studies highlighted that altered fecal bile acid levels correlate with intestinal microbiota composition changes and inflammation in IBD. Lithocholic acid (LCA) is a secondary bile acid (SBA) drastically reduced during active IBD but mediates beneficial effects at the mucosal intestinal b...

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Literature Corpus work: e2cb51a2-78f6-51a9-80fc-7aa4c30ed31b
DOI: 10.1101/2025.11.07.686950

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Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip systemDOI 10.1101/2025.11.07.686950Read

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