Article

Novel bile salt analogs reduce lipid accumulation in liver cells with potential to treat both metabolic dysfunction-associated steatotic liver disease and Clostridioides difficile infection

2026-06-16

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) and Clostridioides difficile ( C. difficile ) infection (CDI) are clinically associated, yet there is limited effective treatment for both diseases. Bile salt analogs (BSAs) have demonstrated potential in treating either MASLD or CDI. We screened a library of BSAs (n=112) previously synthesized as potential inhibitors of C. difficile spore germina...

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Literature Corpus work: 271bc39b-01d3-5632-add8-e9eed367b29f
DOI: 10.64898/2026.06.11.731657

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Novel bile salt analogs reduce lipid accumulation in liver cells with potential to treat both metabolic dysfunction-associated steatotic liver disease and Clostridioides difficile infectionDOI 10.64898/2026.06.11.731657Read

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